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There is increasing evidence that free radical damage may contribute to the devlopment of Alzheimer's disease and Parkinson's disease. This study determined plasma levels of antioxidants in 79 patients with Alzheimer's disease, 37 patients with vascular dementia, 18 patients with Parkinson's disease and dementia and 41 patients with Parkinson's disease, compared to matched controls.
Plasma levels of vitamins A, C and E were decreased in patints with Alzheimer's disease and vascular dementia and vitamin C levels wr also low in patients with Parkinson's disease and dementia. Plasma lycopene levels were low in patients with Parkinson's disease and dementia and beta-carotene concentrations were low in patients with vascular dementia.
Antioxidant levels were not depleted in the group with Parkinson's disease alone.
The researchers conclude that excessive free-radical activity occurs in dementia, especially in vascular dementia and Alxzheimer's disease and is manifest as a decrease in plasma chain-breaking antioxidants, especially vitamins A, C, and E.
Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia, and Parkinson's disease.
QJ Med 92 (1999)
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